Tideglusib

1 1

Selleck Chemicals

S2823-50MG

€167,00 EUR
€167,00 EUR
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Tideglusib is an inhibitor of GSK-3 used in studies of PI3K-Akt-mTOR Signaling and Wnt Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and beta-catenin-dependent transcription and developmental signaling in cancer, cell signaling, and developmental biology models.

By inhibiting GSK-3, Tideglusib can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and beta-catenin-dependent transcription and developmental signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving GSK-3
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and Wnt Signaling
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Tideglusib is appropriate when a defined chemical perturbant is needed to connect GSK-3 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
GSK-3
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • Wnt Signaling
Research Area:
Cancer • Cell Signaling • Developmental Biology • Neuroscience
CAS No.:
865854-05-3
Molecular Weight:
334.39
Formula:
C₁₉H₁₄N₂O₂S
SMILES:
C1=CC=C(C=C1)CN2C(=O)N(SC2=O)C3=CC=CC4=CC=CC=C43
InChIKey:
PMJIHLSCWIDGMD-UHFFFAOYSA-N
PubChem:
11313622
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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