Tozasertib (VX-680, MK-0457)

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Selleck Chemicals

S1048-25MG

€144,00 EUR
€144,00 EUR
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Tozasertib (VX-680, MK-0457) is an inhibitor of Aurora Kinases and FLT3 and related targets used in studies of MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation in apoptosis, autophagy, and cancer models.

By inhibiting Aurora Kinases and FLT3 and related targets, Tozasertib (VX-680, MK-0457) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Aurora Kinases and FLT3 and related targets
  • Pathway perturbation studies connected to MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Tozasertib (VX-680, MK-0457) is appropriate when a defined chemical perturbant is needed to connect Aurora Kinases and FLT3 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Aurora Kinases • FLT3 • AURKA • AURKB
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • JAK-STAT Signaling • Cell Cycle Regulation
Research Area:
Apoptosis • Autophagy • Cancer • Cell Cycle
CAS No.:
639089-54-6
Molecular Weight:
464.59
Formula:
C₂₃H₂₈N₈OS
SMILES:
CC1=CC(=NN1)NC2=CC(=NC(=N2)SC3=CC=C(C=C3)NC(=O)C4CC4)N5CCN(CC5)C
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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