Trametinib DMSO solvate (GSK1120212B)

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Selleck Chemicals

S4484-5MG

€144,00 EUR
€144,00 EUR
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Trametinib DMSO solvate (GSK1120212B) is an inhibitor of MEK1 and MEK2 used in studies of MAPK / ERK Signaling and Apoptosis and related signaling programs. In practice, this places the compound in experiments that measure mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and caspase-associated cell-death signaling and survival decisions in apoptosis, autophagy, and cancer models.

By inhibiting MEK1 and MEK2, Trametinib DMSO solvate (GSK1120212B) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and caspase-associated cell-death signaling and survival decisions. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving MEK1 and MEK2
  • Pathway perturbation studies connected to MAPK / ERK Signaling and Apoptosis and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Trametinib DMSO solvate (GSK1120212B) is appropriate when a defined chemical perturbant is needed to connect MEK1 and MEK2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
MEK1 • MEK2
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • Apoptosis • Autophagy
Research Area:
Apoptosis • Autophagy • Cancer • Cell Signaling
CAS No.:
1187431-43-1
Molecular Weight:
693.53
Formula:
C₂₈H₂₉FIN₅O₅S
SMILES:
CN1C(=O)C(=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC4=C(F)C=C(I)C=C4)C5=CC=CC(=C5)NC(C)=O)C.C[S](C)=O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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