Tropifexor (LJN452)

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Selleck Chemicals

S8733-2MG

€242,00 EUR
€242,00 EUR
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Tropifexor (LJN452) is an agonist of FXR used in studies of GPCR Signaling and Hormone Signaling and related signaling programs. In practice, this places the compound in experiments that measure receptor-driven second-messenger signaling and desensitization dynamics and ligand-dependent transcriptional programs and endocrine regulation in endocrinology and metabolism models.

By activating FXR, Tropifexor (LJN452) can be used to examine receptor-driven second-messenger signaling and desensitization dynamics and ligand-dependent transcriptional programs and endocrine regulation. The nuclear receptor annotation adds relevance to reporter-gene, receptor-binding, and transcriptional assays, together with downstream-response mapping in the same experimental setting. In endocrinology and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving FXR
  • Pathway perturbation studies connected to GPCR Signaling and Hormone Signaling and related signaling programs
  • Agonist-response and downstream signaling studies
  • Reporter-gene, receptor-binding, and transcriptional assays

Overall, Tropifexor (LJN452) is appropriate when a defined chemical perturbant is needed to connect FXR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in endocrinology and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
FXR
Target Class:
Nuclear Receptor
Pathways:
GPCR Signaling • Hormone Signaling • Metabolic Signaling
Research Area:
Endocrinology • Metabolism
CAS No.:
1383816-29-2
Molecular Weight:
603.58
Formula:
C₂₉H₂₅F₄N₃O₅S
SMILES:
C1CC1C2=C(C(=NO2)C3=CC=CC=C3OC(F)(F)F)COC4CC5CCC(C4)N5C6=NC7=C(C=C(C=C7S6)C(=O)O)F
InChIKey:
VYLOOGHLKSNNEK-UHFFFAOYSA-N
PubChem:
121418176
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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