UHRF1 Antibody

About the Target

Ubiquitin-like with PHD and RING Finger domains 1 (UHRF1), also known as Inverted CCAAT box-binding protein of 90 kDa (ICBP90), serves as a crucial epigenetic regulator bridging DNA methylation and histone modifications. UHRF1 is a critical protein that maintains cellular epigenetic integrity by orchestrating DNA methylation patterns and histone modifications.

Reported cellular context includes nucleus, which can matter when signal is compared across treatments or changing cell states. Following UHRF1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.

Research Context

UHRF1 is commonly interpreted in the context of cancer, developmental biology, and epigenetics research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.

Consider these angles when interpreting target-level changes:

• signal enrichment within nucleus relative to the broader cellular background
• changes associated with proliferative state, oncogenic signaling, or treatment response
• stage-dependent patterns during differentiation, morphogenesis, or lineage commitment
• links between target behavior and transcriptional or chromatin-state changes

Variant Considerations

If your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for UHRF1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.

Standardize sampling time, control choice, and downstream analysis thresholds so apparent differences in UHRF1 reflect biology rather than handling. When interpreting UHRF1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.

For multi-run studies, a shared reference condition can keep UHRF1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.