Vacuolin-1

1 1

Selleck Chemicals

S6912-5MG

€144,00 EUR
€144,00 EUR
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Vacuolin-1 is an inhibitor of Autophagy used in studies of PI3K-Akt-mTOR Signaling and Autophagy. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and autophagic flux, lysosomal turnover, and stress adaptation in autophagy models.

By inhibiting Autophagy, Vacuolin-1 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and autophagic flux, lysosomal turnover, and stress adaptation. The autophagy modulator annotation adds relevance to autophagy-flux and lysosomal-response studies, together with downstream-response mapping in the same experimental setting. In autophagy models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Autophagy
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and Autophagy
  • Concentration-response inhibition and target-dependence studies
  • Autophagy-flux and lysosomal-response studies

Overall, Vacuolin-1 is appropriate when a defined chemical perturbant is needed to connect Autophagy with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Autophagy
Target Class:
Autophagy Modulator
Pathways:
PI3K-Akt-mTOR Signaling • Autophagy
Research Area:
Autophagy
CAS No.:
351986-85-1
Molecular Weight:
577.42
Formula:
C₂₆H₂₄IN₇O
SMILES:
IC1=CC=CC(=C1)/C=N/NC2=NC(=NC(=N2)N(C3=CC=CC=C3)C4=CC=CC=C4)N5CCOCC5
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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