Valspodar

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Selleck Chemicals

S8130-1MG

€488,00 EUR
€488,00 EUR
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Valspodar is an inhibitor of P-gp used in studies of transporter biology. In practice, this places the compound in experiments that measure substrate uptake, efflux, and membrane-transport control in cancer and infectious disease models. Dose-response comparison, orthogonal validation, and secondary assay follow-up can further sharpen mechanistic interpretation.

By inhibiting P-gp, Valspodar can be used to examine substrate uptake, efflux, and membrane-transport control. This target class is commonly examined through transport, uptake/efflux, and permeability assays, together with downstream-response mapping. In cancer and infectious disease models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving P-gp
  • Concentration-response inhibition and target-dependence studies
  • Transport, uptake/efflux, and permeability assays
  • Phenotypic profiling in cancer and infectious disease models

Overall, Valspodar is appropriate when a defined chemical perturbant is needed to connect P-gp with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and infectious disease models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
P-gp
Target Class:
Transporter
Research Area:
Cancer • Infectious Disease
CAS No.:
121584-18-7
Molecular Weight:
1214.62
Formula:
C₆₃H₁₁₁N₁₁O₁₂
SMILES:
CC=CCC(C)C(=O)C1C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)C
InChIKey:
YJDYDFNKCBANTM-UHFFFAOYSA-N
PubChem:
5281884
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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