VCAM1 (CD106) Antibody - FFPE Validated

Scientific Overview

To connect mechanism with measurement, this antibody lets you investigate VCAM1 in pathway-driven studies. VCAM1 is a structural regulator of intercellular boundaries and tissue architecture. Many projects interpret this target alongside interacting partners, upstream cues, and downstream readouts.

In some datasets and protocols, it is referenced by the gene symbol CD106.

Research Relevance

Researchers often monitor junctional targets when studying epithelial integrity, remodeling, and motility. Considering complex membership and compartment shifts can clarify whether changes reflect signaling or redistribution.

When cell-state transitions occur, this target may change alongside partners in the same compartment or pathway neighborhood. Blood-brain barrier models often monitor junction regulation alongside permeability-focused measurements.

When building a narrative around the target, it helps to track:

• subcellular redistribution at contact sites versus cytoplasm
• changes in complex assembly with scaffold or adaptor proteins
• co-localization patterns with cytoskeletal elements

Application-Specific Context

Because fixation can mask epitopes, fixed-section oriented formats aim to maintain recognition after standard deparaffinization and retrieval steps. Think about how preparation affects epitope accessibility, and interpret patterns alongside morphology and compartment markers as needed. If signaling is transient, sampling time can be as important as condition.

When interpreting VCAM1, consider whether changes track with compartment identity, cell density, or perturbation timing; these factors can influence apparent signal without implying a direct causal link.

The fixed-section option supports mechanistic reading of VCAM1 when interactions and context are the focus.