VX-803 (M4344)

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Selleck Chemicals

S9639-5MG

€461,00 EUR
€461,00 EUR
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VX-803 (M4344) is an inhibitor of ATR and ATM and related targets used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control in cancer, cell signaling, and dna damage / repair models.

By inhibiting ATR and ATM and related targets, VX-803 (M4344) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage / repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving ATR and ATM and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, VX-803 (M4344) is appropriate when a defined chemical perturbant is needed to connect ATR and ATM and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage / repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
ATR • ATM • CHK1
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • DNA Damage Response
Research Area:
Cancer • Cell Signaling • DNA Damage / Repair
CAS No.:
1613191-99-3
Molecular Weight:
541.55
Formula:
C₂₅H₂₉F₂N₉O₃
SMILES:
C1CN(CCC1C(=O)N2CCN(CC2)C3COC3)C4=C(C=NC=C4NC(=O)C5=C6N=CC(=CN6N=C5N)F)F
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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