WZ3146

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Selleck Chemicals

S1170-5MG

€167,00 EUR
€167,00 EUR
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WZ3146 is an inhibitor of EGFR used in studies of PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in cancer and cell signaling models.

By inhibiting EGFR, WZ3146 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving EGFR
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, WZ3146 is appropriate when a defined chemical perturbant is needed to connect EGFR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
EGFR
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • MAPK / ERK Signaling
Research Area:
Cancer • Cell Signaling
CAS No.:
1214265-56-1
Molecular Weight:
464.95
Formula:
C₂₄H₂₅ClN₆O₂
SMILES:
CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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