XL147 analogue

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Selleck Chemicals

S1118-10MG

€167,00 EUR
€167,00 EUR
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XL147 analogue is an inhibitor of PI3K beta and PI3K alpha and related targets used in studies of PI3K-Akt-mTOR Signaling and Apoptosis. It is especially relevant in apoptosis, cancer, and cell signaling models, where defined compound exposure can be linked to growth-factor signaling, survival control, and nutrient-sensing outputs and caspase-associated cell-death signaling and survival decisions.

By inhibiting PI3K beta and PI3K alpha and related targets, XL147 analogue can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and caspase-associated cell-death signaling and survival decisions. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PI3K beta and PI3K alpha and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and Apoptosis
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, XL147 analogue is appropriate when a defined chemical perturbant is needed to connect PI3K beta and PI3K alpha and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PI3K beta • PI3K alpha • PI3K delta • PI3K gamma
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • Apoptosis
Research Area:
Apoptosis • Cancer • Cell Signaling • Immunology
CAS No.:
956958-53-5
Molecular Weight:
448.52
Formula:
C₂₁H₁₆N₆O₂S₂
SMILES:
CC1=CC=C(C=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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