XL228

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Selleck Chemicals

S1272-5MG

€164,00 EUR
€164,00 EUR
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XL228 is an inhibitor of AURKA and IGF-1R used in studies of PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs. It is especially relevant in angiogenesis, cancer, and cell cycle models, where defined compound exposure can be linked to growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling.

By inhibiting AURKA and IGF-1R, XL228 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, cancer, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving AURKA and IGF-1R
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, XL228 is appropriate when a defined chemical perturbant is needed to connect AURKA and IGF-1R with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
AURKA • IGF-1R
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • MAPK / ERK Signaling • Cell Cycle Regulation
Research Area:
Angiogenesis • Cancer • Cell Cycle • Cell Signaling
CAS No.:
898280-07-4
Molecular Weight:
437.54
Formula:
C₂₂H₃₁N₉O
SMILES:
CC(C)C1=NOC(=C1)CNC2=NC(=CC(=N2)N3CCN(C)CC3)NC4=N[NH]C(=C4)C5CC5
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.