Zebularine (NSC 309132)
Selleck Chemicals
SKU:S7113-10MG
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Zebularine (NSC 309132) is an inhibitor of DNA Methyltransferases and Transferases used in studies of Epigenetic Regulation and Metabolic Signaling. In practice, this places the compound in experiments that measure chromatin-state control, histone modification, and transcriptional regulation and metabolic regulation, energy sensing, and enzyme-linked homeostasis in cancer, epigenetics, and metabolism models.
By inhibiting DNA Methyltransferases and Transferases, Zebularine (NSC 309132) can be used to examine chromatin-state control, histone modification, and transcriptional regulation and metabolic regulation, energy sensing, and enzyme-linked homeostasis. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In cancer, epigenetics, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving DNA Methyltransferases and Transferases
- Pathway perturbation studies connected to Epigenetic Regulation and Metabolic Signaling
- Concentration-response inhibition and target-dependence studies
- Chromatin, epigenetic, and gene-expression profiling
Overall, Zebularine (NSC 309132) is appropriate when a defined chemical perturbant is needed to connect DNA Methyltransferases and Transferases with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, epigenetics, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- DNA Methyltransferases • Transferases
- Target Class:
- Epigenetic Regulator
- Pathways:
- Epigenetic Regulation • Metabolic Signaling
- Research Area:
- Cancer • Epigenetics • Metabolism
- CAS No.:
- 3690-10-6
- Molecular Weight:
- 228.2
- Formula:
- C₉H₁₂N₂O₅
- SMILES:
- C1=CN(C(=O)N=C1)C2C(C(C(O2)CO)O)O
- InChIKey:
- RPQZTTQVRYEKCR-WCTZXXKLSA-N
- PubChem:
- 100016
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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